Science is hope.
We’re working to...
Dream it.
It all begins with questions. Our lab is interested in how epigenetic processes impact normal cells and how these intricate processes become deranged in cancer. How does the p53-related protein p63 affect development, stem cells, aging, and cancer? Which epigenetic factors are vulnerabilities of cancer cells? Can these factors be exploited to treat human cancer?
Build it.
We make use of cutting-edge genomic approaches. We use chromosome engineering to manipulate the mouse genome to establish mouse models of human syndromes with copy number variations, such as schizophrenia, autism, and cancer. Gene editing in mouse and human cells allows us to turn specific genes on, disrupt them, and to precisely modify them to assess function of the encoded protein.
Grow it.
We need to work together. Our group is made up of individuals from across the globe who have had different life experiences that have shaped their interests and made them unique. This makes for an effective team with complementary expertise that is committed to making the world a better place. We work hand-in-hand with surgeons, oncologists, and pathologists in order to bring our discoveries towards the bedside.
Share it.
We share our science on numerous levels. We educate future generations of scientists to nurture and inspire budding academics and clinicians of all ages. By sharing our stories with the general public, we are able to get input on how our work can have the broadest impact on the community, while in parallel offering insight on the questions we are asking.